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MC3482
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MC3482图片
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议

产品介绍
MC3482是一种特异性sirtuin5(SIRT5)抑制剂。

Cell experiment:

MDA-MB-231 and C2C12 cells are treated with 50μM of SIRT5 inhibitor MC3482 for 24 h. Ammonia levels are measured in the culture medium every other day[1].

产品描述

MC3482 is a specific sirtuin5 (SIRT5) inhibitor.

MC3482 inhibits sirtuin5. 50 μM MC3482 inhibits SIRT5 desuccinylating activity without affecting SIRT5 intracellular expression levels. Autophagy and mitophagy increase in SIRT5-silenced cells and in WT cells treated with MC3482 and decrease in SIRT5-overexpressing cells[1].

[1]. Polletta L, et al. SIRT5 regulation of ammonia-induced autophagy and mitophagy. Autophagy. 2015;11(2):253-70.