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Thioquinapiperifil dihydrochloride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Thioquinapiperifil dihydrochloride图片
CAS NO:204077-66-7
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Thioquinapiperifil dihydrochloride (KF31327) 是有效的、选择性的、非竞争性的磷酸二酯酶 (PDE-5) (IC50 为 0.074 nM) 的抑制剂，可用于性成熟的研究。
Cas No.204077-66-7
别名KF31327
Canonical SMILES[H]Cl.[H]Cl.S=C1NC2=CC3=C(NCC4=CC=CC=C4N5CCC(CO)CC5)N=CN=C3C=C2N1CC
分子式C24H30Cl2N6OS
分子量521.51
溶解度DMSO : 125 mg/mL (239.69 mM)
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Thioquinapiperifil dihydrochloride (KF31327), a potent, selective and non-competitive phosphodiesterase-5 (PDE-5, IC50 of 0.074 nM) inhibitor, is used for sexual enhancement study[1][2].

Thioquinapiperifil can be found in dietary supplements[1].Thioquinapiperifil dihydrochloride (KF31327) (0.1-10 µM) concentration dependently inhibits platelet aggregation. In the absence of nitroglycerin, higher concentrations 1 and 10 µM of Thioquinapiperifil dihydrochloride (KF31327) are required to inhibit platelet aggregation[2].Thioquinapiperifil dihydrochloride (KF31327) and shows significant increase in cyclic GMP at 10 µM. After 5 min incubation, the mean cyclic GMP levels of Thioquinapiperifil dihydrochloride (KF31327)-treated cells is 0.95±0.17 pmol/108 cells[2].

References:
[1]. Nahoko Uchiyama, et al. Determination of a new type of phosphodiesterase-5 inhibitor, thioquinapiperifil, in a dietary supplement promoted for sexual enhancement. Chem Pharm Bull (Tokyo). 2008 Sep;56(9):1331-4.
[2]. R Hirose, et al. KF31327, a new potent and selective inhibitor of cyclic nucleotide phosphodiesterase 5. Eur J Pharmacol. 2001 Nov 9;431(1):17-24.