CAS NO: | 1246818-80-3 |
包装 | 价格(元) |
500µg | 电议 |
1mg | 电议 |
Cas No. | 1246818-80-3 |
别名 | 盐酸氨溴索D5 |
Canonical SMILES | O[C@@](C([2H])([2H])C1)([2H])C([2H])([2H])C[C@@H]1NCC2=C(C(Br)=CC(Br)=C2)N |
分子式 | C13H13Br2D5N2O |
分子量 | 383.1 |
溶解度 | Acetonitrile: soluble,DMSO: soluble,Methanol: soluble,Water: soluble |
储存条件 | -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Ambroxol-d5is intended for use as an internal standard for the quantification of ambroxol by GC- or LC-MS. Ambroxol is an expectorant and active metabolite of bromhexine.1It decreases short-circuit currents in electrically stimulated isolated canine tracheal epithelial cells when applied submucosally (IC50= 60 nM).2Ambroxol (100 µM) decreases IL-13-induced production of mucin 5AC (MUC5AC) in primary human airway epithelial cells and inhibits IL-13-induced decreases in the mucociliary transport rate of endogenous particles in the same cells.3Ambroxol increases phenol red secretion, a marker of expectorant activity, in mice when administered at doses of 30, 60, or 120 mg/kg.4Formulations containing ambroxol have been used in the treatment of acute or chronic respiratory conditions. 1.Malerba, M., and Ragnoli, B.Ambroxol in the 21st century: Pharmacological and clinical updateExpert Opin. Drug Metab. Toxicol.4(8)1119-1129(2008) 2.Tamaoki, J., Chiyotani, A., Yamauchi, F., et al.Ambroxol inhibits Na+ absorption by canine airway epithelial cells in cultureJ. Pharm. Pharmacol.43(12)841-843(1991) 3.Seagrave, J., Albrecht, H.H., Hill, D.B., et al.Effects of guaifenesin, N-acetylcysteine, and ambroxol on MUC5AC and mucociliary transport in primary differentiated human tracheal-bronchial cellsRespir. Res.13(1)98(2012) 4.Menezes, P.M.N., Brito, M.C., Sousa de SÁ, P.G., et al.Analytical and pharmacological validation of the quantification of phenol red in a mouse model: An optimized method to evaluate expectorant drugsJ. Pharmacol. Toxicol. Methods98106586(2019) |