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CSF1R-IN-1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CSF1R-IN-1图片
CAS NO:2095849-04-8
包装与价格：
包装价格(元)
250mg电议
500mg电议

产品介绍
CSF1R-IN-1是CSF1R的抑制剂，IC50为0.5nM。
Cas No.2095849-04-8
Canonical SMILESCC1=CC=C(NC(C2=CC=CC(C(F)(F)F)=C2)=O)C=C1NC(C3=CC(C4=CN(C)N=C4)=CN=C3)=O
分子式C25H20F3N5O2
分子量479.45
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CSF1R-IN-1 is a CSF1R inhibitor with an with an IC50 of 0.5 nM.

CSF1R is thought to play an important role in recruitment and differentiation of tumor-associated macrophages (TAMs). CSF1R-IN-1 (compound 22) shows good intestinal permeability in a Caco2 assay[1].

CSF1R-IN-1 has favorable pharmacokinetics when dosed orally to mice. It appears suitable for in vivo pharmacology testing in the appropriate preclinical tumor model to demonstrate proof of concept.[1].|| Animal Model:|Male CD-1 mice, 25-35 grams (8-11 weeks old)[1]|Dosage:|2 mg/kg IV or 10 mg/kg orally (Per Os)|Administration:|i.v. or oral|Result:|

[1]. Ramachandran SA, et al. Design, synthesis and optimization of bis-amide derivatives as CSF1R inhibitors. Bioorg Med Chem Lett. 2017 May 15;27(10):2153-2160.