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4-oxo-27-TBDMS Withaferin A
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
4-oxo-27-TBDMS Withaferin A图片
CAS NO:1214886-31-3
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
4-oxo-27-TBDMS Withaferin A 是一种 withaferin A 衍生物，对肿瘤细胞具有有效的抗增殖作用。4-oxo-27-TBDMS Withaferin A 可诱导肿瘤细胞凋亡。 4-oxo-27-TBDMS Withaferin A 是一种抗癌剂。
Cas No.1214886-31-3
Canonical SMILESO=C(C=C1)[C@@]2(C)[C@@]([C@H]3C[C@]4([H])[C@]2([H])CC[C@@]5(C)[C@@]4([H])CC[C@]5([H])[C@H](C)[C@@]6([H])CC(C)=C(CO[Si](C)(C)C(C)(C)C)C(O6)=O)(O3)C1=O
分子式C34H50O6Si
分子量582.9
溶解度DMF: 5mg/mL,DMSO: 5mg/mL,DMSO:PBS (pH 7.2) (1:1): 0.5mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

4-oxo-27-TBDMS Withaferin A is a derivative of the steroidal lactone withaferin A that has anticancer activity.1 It is cytotoxic to A2780 ovarian cancer cells (IC50 = 17 μM) but not to carboplatin-resistant A2780 (A2780/CP70) cells (IC50 = >100 μM). It is selective for A2780 cells over non-cancerous ARPE19 cells (IC50 = 1,660 μM). 4-oxo-27-TBDMS Withaferin A induces DNA fragmentation in A2780 cells.

References
1. Perestelo, N.R., Llanos, G.G., Reyes, C.P., et al. Expanding the chemical space of withaferin A by incorporating silicon to improve its clinical potential on human ovarian carcinoma cells. J. Med. Chem. 62(9), 4571-4585 (2019).