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Sophocarpine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sophocarpine图片
CAS NO:6483-15-4
包装:20mg
市场价:357元

产品介绍
槐果碱是从传统中草药苦参中提取的重要生物碱之一,具有抗病毒、抗肿瘤、抗炎等多种药理作用。
Cas No.6483-15-4
别名槐果碱
化学名(41S,7aS,13aR,13bR)-2,3,5,6,7,7a,8,13,13a,13b-decahydro-1H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10(41H)-one
Canonical SMILESO=C1N2[C@@](C([H])([H])C([H])=C1[H])([H])[C@]3([H])[C@@]([C@](C([H])([H])C([H])([H])C4([H])[H])([H])C2([H])[H])([H])N4C([H])([H])C([H])([H])C3([H])[H]
分子式C15H22N2O
分子量246.35
溶解度DMSO: 2 mg/ml,Ethanol: 1 mg/ml *
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Sophocarpine (monohydrate) is one of the significant alkaloid extracted from the traditional herb medicine Sophora flavescens which has many pharmacological properties such as anti-virus, anti-tumor, anti-inflammatory. Sophocarpine (monohydrate) significantly inhibits the growth of gastric cancer (GC) cells through multiple mechanisms such as induction of autophagy, activation of cell apoptosis and down-regulation of cell survival PI3K/AKT signaling pathway. Sophocarpine (monohydrate) has been demonstrated to have anti-tumor activity in various cancer cells, including hepatocellular carcinoma, prostate cancer and colorectal cancer[1].

References:
[1]. Huang Y, et al. Sophocarpine inhibits the growth of gastric cancer cells via autophagy and apoptosis. Front Biosci (Landmark Ed). 2019 Mar 1;24:616-627.