| CAS NO: | 61-90-5 |
| 包装 | 价格(元) |
| 250g | 电议 |
| 100g | 电议 |
| Cas No. | 61-90-5 |
| 别名 | L-亮氨酸 |
| 化学名 | (2S)-2-amino-4-methylpentanoic acid |
| Canonical SMILES | CC(C)CC(C(=O)O)N |
| 分子式 | C6H13NO2 |
| 分子量 | 131.2 |
| 储存条件 | Store at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1]. L-Leucine (10 mM) treatment impairs endocrine progenitor cell development[1].In E13.5 rat pancreatic explants, in absence of added L-Leucine, Ngn3 mRNA levels increased after 1 day of culture, peaked on day 3, and then decreased. When L-Leucine is added, a dramatic decrease is observed in Ngn3 mRNA levels. This decrease in Ngn3 mRNA levels was paralleled by a decrease in the number of Ngn3-expressing cells (4728±408 vs. 959±28; PNgn3, its target Insm1, and insulin[1]. Leucine stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing mTORC1 activation. L-Leucine increases intracellular HIF-1α levels and activates the HIF-1α signaling pathway, and these two effects are mediated by the mTOR signaling pathway. This process results in Ngn3 repression and, consequently, decreases β-cell differentiation[1]. References: |
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