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GRL-0496
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GRL-0496图片
CAS NO:1087243-14-8
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
GRL-0496 是一种有效的氯吡啶酯衍生的 SARS-CoV 3CLpro 抑制剂,IC50 值为 30 nM。GRL-0496 显示出最佳的 SARS-CoV 抗病毒活性,EC50 值为 6.9 μM。
Cas No.1087243-14-8
分子式C14H9ClN2O2
分子量272.69
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

GRL-0496 is a potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitor, with an IC50 of 30 nM in both enzyme inhibitory and antiviral assays. GRL-0496 shows SARS-CoV antiviral activity, with an EC50 of 6.9 μM[1].

GRL-0496 shows the best SARS-CoV antiviral activity, with an EC EC50 of 6.9 μM[1].

[1]. Ghosh AK, et, al. Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5684-8.