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2′-Deoxy-2′-fluoroguanosine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
2′-Deoxy-2′-fluoroguanosine图片
CAS NO:78842-13-4
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
100mg电议

产品介绍
2′-Deoxy-2′-fluoroguanosine，一种核苷类似物，是有效的流感病毒 (influenza virus) 抑制剂，抑制 A 型和 B 型流感病毒的 EC90 值<0.35 µM。2′-Deoxy-2′-fluoroguanosine 可显着抑制流感病毒在上呼吸道中的复制，从而改善发烧和鼻腔炎症。
Cas No.78842-13-4
别名2'-脱氧-2'-氟鸟苷；2'-氟脱氧鸟苷；2'-氟-2'-脱氧鸟苷
Canonical SMILESO=C1C2=C(NC(N)=N1)N([C@]3([H])O[C@@H]([C@H]([C@H]3F)O)CO)C=N2
分子式C10H12FN5O4
分子量285.23
溶解度DMSO : 50 mg/mL (175.30 mM)
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

2′-Deoxy-2′-fluoroguanosine, a nucleoside analog, is a potent inhibitor of influenza virus strains, with an EC90 of<0.35 µM for influenza virus A and B strains. 2′-Deoxy-2′-fluoroguanosine significantly inhibits replication of influenza virus in the upper respiratory tract, resulting in amelioration of fever and nasal inflammation[1][2].

References:
[1]. Tisdale M, et, al. Inhibition of influenza virus transcription by 2'-deoxy-2'-fluoroguanosine. Antimicrob Agents Chemother. 1995 Nov;39(11):2454-8.
[2]. Jakeman KJ, et, al. Efficacy of 2'-deoxy-2'-fluororibosides against influenza A and B viruses in ferrets. Antimicrob Agents Chemother. 1994 Aug;38(8):1864-7.