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IR415
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
IR415图片
CAS NO:452967-14-5
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
IR415是有效的抗HBV试剂(anti-HBVagent)，可通过阻断HBx的活性来抑制HBV复制。IR415选择性地与HBx相互作用(Kd=2nM)并阻断HBV介导的RNAi抑制，逆转HBx蛋白对Dicer核糖核酸内切酶活性的抑制作用。
Cas No.452967-14-5
Canonical SMILESS=C(NCCCN1C=CN=C1)NC2=CC=C(F)C=C2F
分子式C13H14F2N4S
分子量296.34
溶解度DMSO: 125 mg/mL (421.81 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

IR415 is a potent anti-HBV agent and inhibits HBV replication by blocking the HBx activity. IR415 selectively interacts with HBx (Kd=2 nM) and blocks HBV-mediated RNAi suppression, reverses the inhibitory effect of HBx protein on the activity of the dicer endoribonuclease[1]. HBx: hepatitis B virus X protein.

Hepatitis B virus X protein (HBx) as a suppressor of host defenses consisting of RNAi-based silencing of viral genes[1].IR415 (50-200 μM) has a dose-dependent inhibitory effect on HBx, with a minimal effective concentration of 50 μM in HepG2/GFP-shRNA line transfected with HBx[1].

[1]. Ghosh S, et al. An RNAi-based high-throughput screening assay to identify small molecule inhibitors of hepatitis B virus replication.J Biol Chem. 2017 Jul 28;292(30):12577-12588.