Naphthofluorescein 抑制 HIF-1 和 Mint3 之间的相互作用。Naphthofluorescein 抑制 Mint3 依赖性 HIF-1 活性和癌细胞和巨噬细胞的糖酵解，在体外没有细胞毒性，在体内没有副作用。 Naphthofluorescein 也是一种荧光 pH 敏感探针，可用于功能性切伦科夫成像。
| Cas No. | 61419-02-1 |
| 别名 | 萘基荧光素,Naphthafluorescein |
| Canonical SMILES | [Na].[Na].Oc1ccc2c(ccc3c2Oc2c4ccc(O)cc4ccc2C23OC(=O)c3ccccc23)c1 |
| 分子式 | C28H16O5 |
| 分子量 | 432.4 |
| 溶解度 | DMF: 10 mg/ml,DMF:PBS (pH 7) (1:10): 0.09 mg/ml,DMSO: 3 mg/ml,Ethanol: 2 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Furin is a proprotein convertase, converting precursor proteins to functional proteins within the Golgi/trans-Golgi secretory pathway. Naphthofluorescein is a cell-permeable inhibitor of furin (IC50 = 12 μM). It inhibits furin-mediated cleavage of the pro-form of membrane type-1 matrix metalloproteinase (MT1-MMP), resulting in decreased levels of active MT1-MMP. This, in turn, suppresses MMP-2 activation and reduces cell motility in CHO cells expressing proMT1-MMP. Napthofluorescein significantly inhibits the invasion of Matrigel by the human fibrosarcoma cell line, HT1080. The effects of this furin inhibitor on other furin-mediated processes, in vivo or in vitro, remain to be determined. |
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