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Darinaparsin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Darinaparsin图片
CAS NO:69819-86-9
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
Darinaparsin (ZIO-101) 是一种有机砷,是一种线粒体靶向剂。 Darinaparsin 可诱导癌细胞凋亡,并具有抗癌作用。
Cas No.69819-86-9
别名Dimethylarsinic glutathione
化学名L-γ-glutamyl-S-(dimethylarsino)-L-cysteinyl-glycine
Canonical SMILESOC(CNC([C@H](CS[As](C)C)NC(CC[C@H](N)C(O)=O)=O)=O)=O
分子式C12H22AsN3O6S
分子量411.3
溶解度0.1mg/mL in ethanol and DMF, 10mg/mL in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Darinaparsin is a dimethylated arsenic linked to glutathione. It is cytotoxic to DU145, LNCaP, and PC3 prostate cancer cells (IC50s = 5-10 &#181M) and patient-derived primary prostate cancer cells (IC50s = 2.5-20 &#181M), as well as Jurkat T cell lymphoma and L540 Hodgkin lymphoma cells (IC50s = 2.7 and 1.3 &#181M, respectively). [1][2] It decreases the tumor-initiating subpopulation in DU145 and PC3 cells and halts the cell cycle in the G2/M phase. Darinaparsin decreases transcription of Gli-2, a transcription factor that mediates Sonic hedgehog signaling, when used at a concentration of 1.5 but not 3 &#181M. It decreases SHP1 phosphatase activity and increases ERK phosphorylation. [2] Darinaparsin reduces tumor growth in DU145 and PC3 prostate cancer mouse xenograft models when administered at a dose of 100 mg/kg every other day.[1]

Reference:
[1]. Bansal, N., Farley, N.J., Wu, L., et al. Darinaparsin inhibits prostate tumor-initiating cells and Du145 xenografts and is an inhibitor of hedgehog signaling. Mol. Cancer Ther. 14(1), 23-30 (2015).
[2]. Ravi, D., Bhalla, S., Gartenhaus, R.B., et al. The novel organic arsenical darinaparsin induces MAPK-mediated and SHP1-dependent cell death in T-cell lymphoma and Hodgkin lymphoma cells and human xenograft models. Clin. Cancer Res. 20(23), 6023-6033 (2014).