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Cytostatin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cytostatin图片
CAS NO:682329-63-1
包装:250μg
市场价:3704元

产品介绍
Cytostatin 是一种有效的选择性 PP2A 抑制剂,具有良好的抗肿瘤活性。 Cytostatin 也是细胞粘附到细胞外基质的抑制剂并诱导细胞凋亡。 Cytostatin 属于 fostriecin 家族的天然产物。
Cas No.682329-63-1
别名磷酸己烷雌酚
Canonical SMILESO=C1O[C@]([C@@H](C)CC[C@H](OP(O)(O)=O)[C@@H](C)[C@@H](O)/C=C\C=C/C=C/C)([H])[C@@H](C)C=C1
分子式C21H33O7P
分子量428.5
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Cytostatin is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 µg/ml, respectively) and B16 cells metastatic activity in mice. It induces apoptosis of FS3 mouse fibrosarcoma cells (IC50 = 3.1 µg/ml). Cytostatin potently and selectively inhibits protein phosphatase 2A (PP2A; IC50 = 29 nM against the catalytic subunit), while having no effect against PP1, PP2B, or PP5.