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JZL 195
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
JZL 195图片
CAS NO:1210004-12-8
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
JZL 195 是一种选择性和有效的双重脂肪酸酰胺水解酶 (FAAH) 和单酰基甘油脂肪酶 (MAGL) 抑制剂，IC50 分别为 2 和 4 nM。
Cas No.1210004-12-8
别名4-硝基苯基4-(3-苯氧基苄基)哌嗪-1-甲酸叔丁酯
化学名4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate
Canonical SMILESO=C(N1CCN(CC2=CC=CC(OC3=CC=CC=C3)=C2)CC1)OC(C=C4)=CC=C4[N+]([O-])=O
分子式C24H23N3O5
分子量433.46
溶解度DMF: 5 mg/ml,DMSO: 1.25 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

JZL195 is a selective and efficacious dual fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) inhibitor with IC50s of 2 and 4 nM, respectively[1].

JZL195 produces near-complete blockade of FP-Rh labeling of both mouse brain FAAH and MAGL at concentrations as low as 100 nM (IC50 values of 13 and 19 nM, respectively)[1].JZL195 inhibits rat and human FAAH and MAGL enzymes with IC50 values in the range of ≈10-100 nM based on competitive ABPP assays[1].

JZL195 (20 mg/kg; i.p.) produces an antinociceptive response in the tail immersion assay[1].

References:
[1]. Long JZ, et al. Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20270-5.
[2]. Anderson WB, et al. Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine inflammatory pain model. Neuropharmacology. 2014 Jun;81:224-30.