| CAS NO: | 2009052-76-8 |
| 包装: | 5mg |
| 市场价: | 3602元 |
| Cas No. | 2009052-76-8 |
| Canonical SMILES | CN1C=CC(COC2=CN=C(C(N)=O)C=C2C3=CC=C(C=C3)F)=N1 |
| 分子式 | C17H15FN4O2 |
| 分子量 | 326.33 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Potent and selective mGlu2 negative allosteric modulator (IC50 = 78 nM). Exhibits > 350-fold selectivity for mGlu2 over mGlu3. Also exhibits selectivity over other mGluRs and a panel of GPCRs, ion channels and transporters. CNS penetrant. Bollinger et al (2017) Design and synthesis of mGlu2 NAMs with improved potency and CNS penetration based on a truncated picolinamide core. ACS Med.Chem.Lett. 8 919 PMID:28947937 |
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