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MS 15203
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MS 15203图片
CAS NO:73912-52-4
包装与价格:
包装价格(元)
5mg电议
25mg电议

产品介绍
MS 15203 是一种有效的选择性 GPR171 激动剂。
Cas No.73912-52-4
别名5-甲基丙烯酰胺基间苯二甲酸,MS0015203
Canonical SMILESCC(C(NC1=CC(C(O)=O)=CC(C(O)=O)=C1)=O)=C
分子式C12H11NO5
分子量249.22
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Potent and selective GPR171 partial agonist (EC50 = 90 nM; 28% inhibition of forskolin activated adenylyl cyclase activity in rat hypothalamic memebranes). Exhibits minimal binding to a panel of ~70 GPCRs and 10 other receptors (<22% of radioligand displaced from the target receptors). Increases neuronal activity in the paraventricular nucleus. Increases food intake and body weight in mice.

Wardman et al (2016) Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake Sci.Signal. 9 PMID:27245612