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DG 041
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DG 041图片
CAS NO:861238-35-9
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
DG 041 是一种有效的、高亲和力和选择性的 EP3 受体拮抗剂,在结合和 FLIPR 试验中的 IC50 分别为 4.6 nM 和 8.1 nM。
Cas No.861238-35-9
Canonical SMILESCC1=CN(C2=C(C=C(C=C12)F)/C=C/C(NS(=O)(C3=CC(Cl)=C(S3)Cl)=O)=O)CC4=C(C=C(C=C4)Cl)Cl
分子式C23H15Cl4FN2O3S2
分子量592.32
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Potent and selective EP3 antagonist (IC50 = 4.6 nM). Inhibits PGE2 facilitation of platelet aggregation in vitro and ex vivo. Displays good plasma and metabolic stability. Does not affect bleeding time in rats. Antiplatelet and antithrombotic.

Markovič et al (2017) Structural features of subtype-selective EP receptor modulators. Drug Discov.Today. 22 57 PMID:27506873 |Singh et al (2009) Antagonists of the EP3 receptor for prostaglandin E2 are novel antiplatelet agents that do not prolong bleeding. ACS Chem.Biol. 4 115 PMID:19193156