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PM 226
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PM 226图片
CAS NO:1949726-13-9
包装:10mg
市场价:3925元

产品介绍
PM 226 是一种选择性大麻素 CB2R 激动剂 (Ki (CB2R)\u003d13 nM; EC50 (CB2R)\u003d39 nM; Ki (CB1R) \u003e40 μM;),在体外和体内具有神经保护特性。
Cas No.1949726-13-9
Canonical SMILESCCCCCCC(C)(C1=CC(OC)=C2C3=C(C(C)(OC2=C1)C)C=NO3)C
分子式C22H31NO3
分子量357.49
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Potent and selective CB2 receptor agonist (Ki = 12.8 nM; EC50 = 38.67 nM). Exhibits negligible affinity for the CB1 receptor (Ki > 40,000 nM) and no activity at the GPR55. Suppresses neuroinflammation by reducing microglial activation in a multiple sclerosis mouse model. BBB permeable; anti-inflammatory and neuroprotective.

Navarro et al (2016) Targeting cannabinoid CB2 receptors in the central nervous system. Medicinal chemistry approaches with focus on neurodegenerative disorders. Front. Neurosci. 10 406 PMID:27679556 |Morales et al (2016) Chromenopyrazole, a versatile cannabinoid scaffold with in vivo activity in a model of multiple sclerosis. J.Med.Chem. 59 6753 PMID:27309150 |Gómez-Cañas et al (2016) Biological characterization of PM226, a chromenoisoxazole, as a selective CB2 receptor agonist with neuroprotective profile. Pharmacol.Res. 110 205 PMID:27013280