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AC 265347
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AC 265347图片
CAS NO:1253901-26-6
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
Biased allosteric modulator of calcium-sensing receptor (CaSR)
Cas No.1253901-26-6
Canonical SMILESCC1=CC(C)=C(C(O)(C2=NC3=CC=CC=C3S2)C)C=C1
分子式C17H17NOS
分子量283.39
溶解度DMSO: 100 mM,Ethanol: 100 mM
储存条件Store at 4℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CaSR biased allosteric modulator (pEC50 = 7.8-8.1). Calcimimetic. Displays ability to bias signalling towards the accumulation of pERK1/2 and IP1. Reduces parathyroid hormone (PTH) levels in rat serum without inducing the release of calcitonin. Exhibits no significant activation of human GABAB or type I PTH receptors. Orally active.

Cook et al (2015) Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics. Br.J.Pharmacol. 172 185 PMID:25220431 |Ma et al (2011) Characterization of highly efficacious allosteric agonists of the human calcium-sensing receptor. J.Pharmacol.Exp.Ther. 337 275 PMID:21239511 |Leach et al (2016) Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor. Cell.Res. 26 574 PMID:27002221