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SB 332235
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SB 332235图片
CAS NO:276702-15-9
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
SB 332235 是一种有效的、具有口服活性的非肽 CXCR2 拮抗剂,IC50 为 7.7 nM。
Cas No.276702-15-9
Canonical SMILESClC1=C(S(=O)(N)=O)C(O)=C(NC(NC2=C(Cl)C(Cl)=CC=C2)=O)C=C1
分子式C13H10Cl3N3O4S
分子量410.66
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Potent CXCR2 antagonist (IC50 = 7.7 nM). Exhibits 285-fold selectivity for CXCR2 over CXCR1. Reduces leukocyte numbers in synovial fluid in acute and chronic rabbit arthritis models. Also reduces synovial fluid eicosanoid and cytokine levels in a rabbit chronic arthritis model. Inhibits proliferation of AML cell lines in vitro.

Podolin et al (2002) A potent and selective nonpeptide antagonist of CXCR2 inhibits acute and chronic models of arthritis in the rabbit. J.Immunol. 169 6435 PMID:12444152 |Schinke et al (2015) IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells. Blood 125 3144 PMID:25810490