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Quin C1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Quin C1图片
CAS NO:786706-21-6
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
Quin C1 是一种高度特异性和有效的甲酰肽受体 2 (FPR2/ALX) 激动剂。
Cas No.786706-21-6
Canonical SMILESO=C1N(NC(C2=CC=C(OCCCC)C=C2)=O)C(C3=CC=C(OC)C=C3)NC4=CC=CC=C41
分子式C26H27N3O4
分子量445.51
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Potent and selective FPR2 agonist (EC50 = 15 nM). Induces Ca2+ mobilization in FPR2 but not FPR1-transfected mast cells. Induces neutrophil chemotaxis and degranulation in vitro. Reduces neutrophil and lymphocyte counts in bronchoalveolar lavage fluid in a mouse lung injury model. Anti-inflammatory.

Zhou et al (2007) Pharmacological characterization of a novel nonpeptide antagonist for formyl peptide receptor-like 1. Mol.Pharmacol. 72 976 PMID:17652444 |Corminboeuf et al (2014) FPR2/ALXR agonists and the resolution of inflammation. J.Med.Chem. 58 537 PMID:25365541