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MRS 5698
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MRS 5698图片
CAS NO:1377273-00-1
包装:1mg
市场价:5939元

产品介绍
MRS 5698 是一种选择性 Gi 蛋白偶联 A3 腺苷受体 (A3AR) 激动剂,对人和小鼠 A3AR 的 Kis 值分别约为 3 nM。
Cas No.1377273-00-1
Canonical SMILESO=[C@](NC)[C@@]1(C2)[C@H]2[C@@H](N3C(N=C(C#CC6=CC(F)=C(F)C=C6)N=C4NCC5=CC(Cl)=CC=C5)=C4N=C3)[C@H](O)[C@@H]1O
分子式C28H23ClF2N6O3
分子量564.97
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

High affinity and selective A3 adenosine receptor agonist (Ki ~ 3 nM); displays >1000-fold selectivity over A1 and A2A adenosine receptors. Reverses mechanoallodynia in several neuropathic pain models in vivo. Orally bioavailable.

Little et al (2015) Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states. Brain 138 28 PMID:25414036 |Tosh et al (2012) Structure-guided design of A3 adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions. J.Med.Chem. 55 4847 PMID:22559880 |Tosh et al (2015) Efficient, large-scale synthesis and preclinical studies of MRS5698, a highly selective A3 adenosine receptor agonist that protects against chronic neuropathic pain. Purinergic Signal. 11 371 PMID:26111639