| CAS NO: | 1443748-47-7 |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 50mg | 电议 |
| Cas No. | 1443748-47-7 |
| Canonical SMILES | O=C(N4CCN(C5=C(C#N)N=CC=C5)C[C@H]4C)C12CC(C3)CC(CC3C2)C1.Cl |
| 分子式 | C22H28N4O.HCl |
| 分子量 | 400.94 |
| 溶解度 | DMSO: 100 mM,Ethanol: 50 mM |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Potent and selective negative allosteric modulator of mGlu1 (IC50 = 99 nM). Exhibits >100-fold selectivity for mGlu1 over mGlu2-8 and 68 other GPCRs, ion channels, kinases and transporters. Brain penetrant. Lovell et al (2013) N-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu1: Identification of VU0469650, a potent and selective tool compound with CNS exposure in rats. Bioorg.Med.Chem.Lett. 23 3713 PMID:23727046 |
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