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ACT 462206
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ACT 462206图片
CAS NO:1361321-96-1
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
ACT 462206 是一种口服有效的 Orexin 1/Orexin 2 双重受体拮抗剂,IC50 分别为 60 nM (Orexin 1) 和 11 nM (Orexin 2)。
Cas No.1361321-96-1
Canonical SMILESCC1=CC(NC([C@@H]2CCCN2S(C3=CC=C(OC)C=C3)(=O)=O)=O)=CC(C)=C1
分子式C20H24N2O4S
分子量388.48
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Potent, dual orexin receptor antagonist (IC50 values are 11 and 60 nM for OX2 and OX1 receptors respectively). Exhibits anxiolytic-like properties in vivo. Brain penetrant.

Boss et al (2014) Structure-activity relationship, biological, and pharmacological characterization of the proline sulfonamide ACT-462206: a potent, brain-penetrant dual orexin 1/orexin 2 receptor antagonist. ChemMedChem. 9 2486 PMID:25147058