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EPPTB
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
EPPTB图片
CAS NO:1110781-88-8
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
EPPTB (EPPTB) 是一种有效且选择性的微量胺相关受体 1 (TAAR1) 拮抗剂（小鼠 TAAR1 的 Ki=0.9 nM），对其他 TAAR 没有显着影响。
Cas No.1110781-88-8
别名EPPTB
Canonical SMILESO=C(NC3=CC(OCC)=CC=C3)C1=CC(C(F)(F)F)=C(N2CCCC2)C=C1
分子式C20H21F3N2O2
分子量378.39
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Trace amine 1 (TA1) receptor antagonist/inverse agonist; exhibits a higher potency at the mouse TA1 receptor than the rat and human TA1 receptors (IC50 values are 27.5, 4539 and 7487 nM, respectively). Blocks the TA1 receptor-mediated activation of an inwardly rectifying K+ current, which increases the firing frequency of dopamine (DA) neurons in the ventral tegmental area. Increases DA potency at the D2 receptor. Also displays inverse agonism, reducing basal cAMP levels in vitro (IC50 = 19 nM).

Bradaia et al (2009) The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in DArgic neurons of the mesolimbic system. Proc.Natl.Acad.Sci.U.S.A. 106 20081 PMID:19892733