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RS 127445 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
RS 127445 hydrochloride图片
CAS NO:199864-86-3
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
RS 127445 hydrochloride 是一种选择性、高亲和力、口服生物可利用的 5-HT2B 受体拮抗剂,pKi 为 9.5。
Cas No.199864-86-3
别名4-(4-氟-1-萘基)-6-(1-甲基乙基)-2-嘧啶胺盐酸盐
Canonical SMILESFC1=C(C=CC=C2)C2=C(C3=CC(C(C)C)=NC(N)=N3)C=C1.Cl
分子式C17H16FN3.HCl
分子量317.79
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

High affinity 5-HT2B receptor antagonist (pKi = 9.5). Displays 1000-fold selectivity for 5-HT2B with good bioavailability.

Bonhaus et al (1999) RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist. Br.J.Pharmacol. 127 1075 PMID:10455251 |Callebert et al (2006) Evidence for a control of plasma serotonin levels by 5-Hydroxytryptamine2B receptors in mice. J.Pharmacol.Exp.Ther. 317 724 PMID:16461587