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Histone-H2A-(107-122)-Ac-OH
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Histone-H2A-(107-122)-Ac-OH图片
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍

Histone-H2A peptide

别名Ac-Gly-Val-Leu-Pro-Asn-Ile-Gln-Ala-Val-Leu-Leu-Pro-Lys-Lys-Thr-Glu-OH
Canonical SMILESCC(NCC(NC(C(C)C)C(NC(CC(C)C)C(N1C(C(NC(CC(N)=O)C(NC(C(CC)C)C(NC(CCC(N)=O)C(NC(C)C(NC(C(NC(CC(C)C)C(NC(CC(C)C)C(N2C(C(NC(CCCCN)C(NC(CCCCN)C(NC(C(C)O)C(NC(C(O)=O)CCC(O)=O)=O)=O)=O)=O)CCC2)=O)=O)=O)C(C)C)=O)=O)=O)=O)=O)CCC1)=O)=O)=O)=O
分子式C81H140N20O23
分子量1762.1
溶解度≥ 176.2mg/mL in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Histone-H2A-(107-122)-Ac-OH, (C81H140N20O23), a peptide with the sequence Ac-Gly-Val-Leu-Pro-Asn-Ile-Gln-Ala-Val-Leu-Leu-Pro-Lys-Lys-Thr-Glu-OH, MW= 1762.1. Histone H2Ais one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Histones are proteins that package DNA into nucleosomes1. Histones are responsible for maintaining the shape and structure of a nucleosome. One chromatin molecule is composed of at least one of each core histones per 100 base pairs of DNA. There are five families of histones known to date; these histones are termed H1/H5, H2A, H2B, H3, and H42.H2A is important for packaging DNA into chromatin. Since H2A packages DNA molecules into chromatin, the packaging process will effect gene expression.H2A has been correlated with DNA modification and epigenetics. H2A plays a major role in determining the overall structure of chromatin. Inadvertently, H2A has been found to regulate gene expression3. DNA modification by H2A occurs in the cell nucleus. Proteins responsible for nuclear import of H2A protein are karyopherin and importin. Recent studies also show that nucleosome assembly protein 1 is also used to transport of H2A into the nucleus so it can wrap DNA. Other functions of H2A have been seen in the histone variant H2A.Z. This variant is associated with gene activation, silencing and suppression of antisense RNA. In addition, when H2A.Z was studied in human and yeast cells, it was used to promote RNA polymerase II recruitment4.

References:
1. Youngson, Robert M. (2006).Collins Dictionary of Human Biology.Glasgow: HarperCollins.
2. Khorasanizadeh, Sepideh. 2004. The Nucleosome: From Genomic Organization to Genomic Regulation. Department of Biochemistry and Molecular Genetics,UniversityofVirginia HealthSystem. Cellular Biology. Volume 116, Issue 2, , Pages 259-272.
3. Marino-Ramirez L, Jordan IK, Landsman D. Multiple independent evolutionary solutions to core histone gene regulation. Genome Biol. 2006;7:R12
4. Marino-Ramirez L, Levine KM, Morales M, Zhang S, Moreland. RT, Baxevanis AD, Landsman D (2011) The histone database: an integrated resource for histones and histone fold-containing proteins. Database (Oxford) bar048