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ferritin heavy chain fragment [Multiple species]
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ferritin heavy chain fragment [Multiple species]图片
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍

Ferritin heavy chain fragment

别名H2N-Tyr-Leu-Asn-Glu-Gln-Val-Lys-Ala-Ile-OH
Canonical SMILESNC(CC1=CC=C(O)C=C1)C(NC(CC(C)C)C(NC(CC(N)=O)C(NC(CCC(O)=O)C(NC(CCC(N)=O)C(NC(C(C)C)C(NC(CCCCN)C(NC(C)C(NC(C(C)CC)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O
分子式C49H80N12O15
分子量1077.23
溶解度≥ 107.7mg/mL in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Sequence: H2N-YLNEQVKAI-OH
Ferritin is a protein of 450 kDa consisting of 24 subunits that is present in every cell type. In vertebrates, these subunits are both the light (L) and the heavy (H) type with an apparent molecular weight of 19 kDA or 21 kDA respectively; their sequences are about 50% homologous. [1] Heart, kidney, and placental ferritins are highly acidic because they are composed of mostly H chains [2] . The ferritin found in cancer cells was found to consist mainly of H chains [3][4].
The heavy chain of Ferritin also possesses ferroxidase activity, this involves the conversion of iron from the ferrous (Fe2+) to ferric (Fe 3+) forms. This limits the deleterious reaction which occurs between ferrous iron and hydrogen peroxide known as the Fenton reaction which produces the highly damaging hydroxyl radical.
If the ferritin level is low, there is a risk for lack of iron, which could lead to anemia.[5] If ferritin is high, there is iron in excess or else there is an acute inflammatory reaction in which ferritin is mobilized without iron excess. For example, ferritins may be high in infection without signalling body iron overload. Ferritin is also used as a marker for iron overload disorders, such as hemochromatosis or hemosiderosis.[6] Recent research has shown that H-Ferritin from melanoma cells may suppress immune responses.[7]

References:
1. Theil, E. (1987). "Ferritin: structure, gene regulation, and cellular function in animals, plants, and microorganisms." Annual review of biochemistry 56 (1): 289–315. doi:10.1146/annurev.bi.56.070187.001445.PMID 3304136.
2. Morikawa K., Oseko F., Morikawa S. A role for ferritin in hematopoiesis and the immune system. Leuk. Lymphoma, 18: 429-433, 1995.
3. Hazard J. T., Drysdale J. W. ferritinaemia in cancer. Nature (Lond.), 265:755-756, 1977.
4. Constanzo F., Colombo M., Staempfli S., Santoro C., Marone M., Frank R., Delius H., Cortese R. Structure of gene and pseudogenes of human apoferritin H.Nucleic Acids Res., 14: 721-736, 1986.
5. Guyatt G, Patterson C, Ali M, Singer J, Levine M, Turpie I, Meyer R (1990). "Diagnosis of iron-deficiency anemia in the elderly". Am J Med 88 (3): 205–9.doi:10.1016/0002-9343(90)90143-2. PMID 2178409.
6. Kennedy A, Kohn M, Lammi A, Clarke S (2004). "Iron status and haematological changes in adolescent female inpatients with anorexia nervosa". J Paediatr Child Health 40 (8): 430–2. doi:10.1111/j.1440-1754.2004.00432.x.PMID 15265182.
7. Gray C. P., Franco A. V., Arosio P., Hersey P. Immunosuppressive effects of melanoma-derived heavy-chain ferritinare dependent on stimulation of IL-10 production. Int. J. Cancer, 92: 843-850, 2001.