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3,5-Diiodothyropropionic Acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
3,5-Diiodothyropropionic Acid图片
CAS NO:1158-10-7
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议

产品介绍
3,5-二碘甲状腺丙酸是一种甲状腺激素类似物,可诱导 α-肌球蛋白重链 mRNA 表达,与甲状腺激素受体 (TR) 结合,TRα1 和 TRβ1 的 Ka 分别为 2.40 和 4.06 M-1 。
Cas No.1158-10-7
别名3,5-二碘甲腺丙酸
化学名4-(4-hydroxyphenoxy)-3,5-diiodo-benzenepropanoic acid
Canonical SMILESIC1=CC(CCC(O)=O)=CC(I)=C1OC2=CC=C(O)C=C2
分子式C15H12I2O4
分子量510.1
溶解度DMSO: Slightly Soluble,Methanol: Slightly Soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述 3,5-Diiodothyropropionic acid (DITPA) is an inotropic thyroid hormone analogue of L-thyroxine that binds to the thyroid hormone receptors TRα and TRβ (Kas = 2.4 and 4.06 x 107 M-1, respectively, for human recombinant receptors).1 DITPA increases mRNA expression of α-myosin heavy chain (α-MHC) in primary rat cardiomyocytes (EC50 = ~0.5 μM). Ex vivo, DITPA prevents myocardial infarction-induced loss of contractility in rabbit cardiomyocytes when administered at a dose of 3.75 mg/kg per day.2 DITPA (3.75 mg/kg per day) increases expression of VEGF, basic fibroblast growth factor (bFGF), angiopoietin-1, and angiopoietin-1 receptor (Tie-2) as well as angiogenesis in non-infarcted cardiac tissue in rats.3 It also decreases infarct size expansion, stimulates arteriolar growth, and inhibits ventricular remodeling post-myocardial infarction in rats when administered at a dose of 3.5 mg/kg per day.4