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(-)-Physostigmine(salicylate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(-)-Physostigmine(salicylate)图片
CAS NO:57-64-7
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
(-)-Physstigmine (salicylate) (Eserine salicylate) 是一种可逆的乙酰胆碱酯酶 (AChE) 抑制剂。
Cas No.57-64-7
别名水杨酸毒扁豆碱; Eserine salicylate
Canonical SMILESCNC(OC1=CC([C@@](CCN2C)(C)[C@@]2([H])N3C)=C3C=C1)=O.OC(C4=C(O)C=CC=C4)=O
分子式C15H21N3O2•C7H6O3
分子量413.5
溶解度DMF: 30 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 1 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

(-)-Physostigmine is an alkaloid that has been found in Calabar beans and a cholinergic agent.1,2It inhibits acetylcholinesterase (AChE; IC50= 0.67 nM).2(-)-Physostigmine (10 µM) inhibits ChE and increases vagal stimulation-induced ACh output in isolated chicken heart.3In vivo, (-)-physostigmine (200 and 400 µg/kg) induces decentralized lower eyelid contractions and increases blood pressure in anesthetized rats.4

1.Proudfoot, A.The early toxicology of physostigmine: a tale of beans, great men and egosToxicol. Rev.25(2)99-138(2006) 2.Ogura, H., Kosasa, T., Kuriya, Y., et al.Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitroMethods Find. Exp. Clin. Pharmacol.22(8)609-613(2000) 3.Dieterich, H.A., Kaffel, H., Kilbinger, H., et al.The effects of physostigmine on cholinesterase activity, storage and release of acetylcholine in the isolated chicken heartJ. Pharmacol. Exp. Ther.199(1)236-246(1976) 4.SzeberÉnyi, J., Varga, A., PongrÁcz, M.F., et al.Centrally mediated contraction of the lower eyelid elicited by anticholinesterases in anaesthetized ratsJ. Pharm. Pharmacol.24(1)85-86(1972)