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JTV 519 fumarate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
JTV 519 fumarate图片
CAS NO:1883549-36-7
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
Cas No.1883549-36-7
化学名1-(2,3-Dihydro-7-methoxy-1,4-benzothiazepin-4(5H)-yl)-3-[4-(phenylmethyl)-1-piperidinyl]-1-propanone fumarate
Canonical SMILESO=C(CCN3CCC(CC4=CC=CC=C4)CC3)N2CCSC1=CC=C(OC)C=C1C2.O=C(/C=C/C(O)=O)O
分子式C25H32N2O2.C4H4O4
分子量540.67
溶解度54.07mg/ml in DMSO
储存条件Store at 4℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ryanodine receptor (RyR) inhibitor; stabilizes RyR2 in a closed conformation. Exhibits antiarrhythmic and cardioprotective properties in vivo.

Hunt et al (2007) K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association. Biochem.J. 404 431 PMID:17313373 |Chen et al (2008) Effect of K201, a novel antiarrhythmic drug on calcium handling and arrhythmogenic activity of pulmonary vein cardiomyocytes. Br.J.Pharmacol. 153 915 PMID:17994112 |Ye et al (2012) Designing calcium release channel inhibitors with enhanced electron donor properties: stabilizing the closed state of ryanodine receptor type 1. Mol.Pharmacol. 81 53 PMID:21989257