您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Ani 9
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Ani 9
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ani 9图片
CAS NO:356102-14-2
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Ani 9 是一种有效的选择性跨膜蛋白 16A (TMEM16A, Anoctamin-1) 阻断剂,IC50 为 77 nM。
Cas No.356102-14-2
化学名2-(4-chloro-2-methylphenoxy)-acetic acid, 2-[(2-methoxyphenyl)methylene]hydrazide
Canonical SMILESClC1=CC=C(OCC(N/N=C/C2=CC=CC=C2OC)=O)C(C)=C1
分子式C17H17ClN2O3
分子量332.8
溶解度25mg/mL in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ani 9 is an inhibitor of the calcium-activated chloride channel (CaCC) anoctamin 1 (ANO1) that blocks ATP-induced apical membrane chloride currents in ANO1-expressing Fischer rat thyroid (FRT) cells (IC50 = 77 nM).[1] It is selective for ANO1 over ANO2 at 10 μM and the cystic fibrosis transmembrane conductance regulator (CFTR) and epithelial sodium channel (ENaC) at 30 μM. Ani 9 inhibits ATP-induced quenching of a fluorescent intracellular halide sensor in PC3 prostate cancer cells and Capan-1 pancreatic carcinoma cells in a concentration-dependent manner.

Reference:
[1]. Seo, Y., Lee, H.K., Park, J., et al. Ani9, A novel potent small-molecule ANO1 inhibitor with negligible effect on ANO2. PLoS One 11(5), e0155771 (2016).