| CAS NO: | 1246820-85-8 |
| 包装: | 1mg |
| 市场价: | 3614元 |
| Cas No. | 1246820-85-8 |
| 别名 | 索他洛尔-D6,MJ 1999-d6 hydrochloride |
| Canonical SMILES | CS(NC1=CC=C(C(O)CNC(C([2H])([2H])[2H])C([2H])([2H])[2H])C=C1)(=O)=O.Cl |
| 分子式 | C12H14D6N2O3S.HCl |
| 分子量 | 314.9 |
| 溶解度 | DMSO: soluble,Methanol: soluble,Water: soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Sotalol-d6 is intended for use as an internal standard for the quantification of sotalol by GC- or LC-MS. Sotalol is a non-selective antagonist of β-adrenergic receptors (ARs) that inhibits β1-, β2-, and β3-ARs with IC50 values ranging from 0.1 to 8.9 μM.1,2,3 Through its effects on β2-ARs, sotalol also blocks outward potassium currents in myocardium, exhibiting Class III antiarrhythmic actions.4,5 |1. Tsuchihashi, H., Nakashima, Y., Kinami, J., et al. Characteristics of 125I-iodocyanopindolol binding to β-adrenergic and serotonin-1B receptors of rat brain: Selectivity of β-adrenergic agents. Jpn. J. Pharmacol. 52(2), 195-200 (1990).|2. Lis, R., Morgan, T.K., Jr., Marisca, A.J., et al. Synthesis of novel (aryloxy) propanolamines and related compounds possessing both class II and class III antiarrhythmic activity. J. Med. Chem 33(10), 2883-2891 (1990).|3. Baker, J.G. The selectivity of β-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors. Br. J. Pharmacol. 144(3), 317-322 (2005).|4. Campbell, T.J., and Williams, K.M. Therapeutic drug monitoring: Antiarrhythmic drugs. Br. J. Clin. Pharmacol. 52, 307-319 (1998).|5. Khairy, P., and Nattel, S. New insights into the mechanisms and management of atrial fibrillation. Can. Med. Assoc. .J. 167(9), 1012-1020 (2002). |
m.cnreagent.com