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ML67-33
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ML67-33图片
CAS NO:1443290-89-8
包装:5mg
市场价:2700元

产品介绍
ML67-33 是一种对温度和机械敏感的 K2P 通道的选择性激活剂。ML67-33 快速可逆地激活 K2P2.1 (TREK-1),在无细胞体系和 HEK293 细胞中 EC50 分别为 36.3 μM 和 9.7 μM。
Cas No.1443290-89-8
Canonical SMILESCC1(C)C2=C(C=CC(Cl)=C2)N(CCC3=NN=NN3)C4=CC=C(Cl)C=C14
分子式C18H17Cl2N5
分子量374.27
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ML67-33 is a selective activator of temperature- and mechano-sensitive K2P channels. ML67-33 rapidly and reversibly affects K2P2.1 (TREK-1) with EC50s of 36.3 μM and 9.7 μM in cell-free and HEK293 cells, respectively[1].

ML67-33 activates K2P channels and mutants with EC50s of 21.8±1.3 μM, 49.4±1.1 μM, 30.2±1.4 μM, and 27.3±1.2 μM for K2P2.1 (TREK-1) W275S, K2P2.1 (TREK-1)-3G, K2P10.1 (TREK-2), K2P4.1 (TRAAK), respectively[1].

[1]. Bagriantsev SN, et al. A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels. ACS Chem Biol. 2013 Aug 16;8(8):1841-51.