您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Lidoflazine
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Lidoflazine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lidoflazine图片
CAS NO:3416-26-0
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议

产品介绍
Lidoflazine 是 HERG K+ 通道的高亲和力阻滞剂。Lidoflazine 也是一种抗心绞痛的钙通道阻滞剂,具有延长 QT 间期和发生室性心律失常的重大风险。
Cas No.3416-26-0
别名利多氟嗪
Canonical SMILESO=C(NC1=C(C)C=CC=C1C)CN2CCN(CCCC(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)CC2
分子式C30H35F2N3O
分子量491.62
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Lidoflazine is a high affinity blocker of the HERG (human ether-a-go-go-related gene) K+ channel. Lidoflazine is an antianginal calcium channel blocker that carries a significant risk of QT interval prolongation and ventricular arrhythmia[1].

Lidoflazine inhibits potently HERG current (IHERG) recorded from HEK 293 cells stably expressing wild-type HERG (IC50 of ~16 nM).

[1]. https://www.ncbi.nlm.nih.gov/pubmed/15135665