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Sematilide(hydrochloride)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Sematilide(hydrochloride)图片
CAS NO:101526-62-9
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
Sematilide (hydrochloride) (CK-1752 hydrochloride) 是一种选择性 IKr 通道阻滞剂。
Cas No.101526-62-9
别名司美利特盐酸盐一水合物,CK-1752 hydrochloride
Canonical SMILESCS(NC1=CC=C(C(NCCN(CC)CC)=O)C=C1)(=O)=O.Cl
分子式C14H23N3O3S.HCl
分子量349.9
溶解度DMF: 12 mg/ml,DMSO: 12 mg/ml,Ethanol: 3 mg/ml,PBS (pH 7.2): 5 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Sematilide is a class III antiarrhythmic agent and an analog of sotalol .1 It prolongs electrically stimulated action potential duration (APD) and increases the effective refractory period (ERP) in isolated guinea pig left atria. Sematilide decreases spontaneous sinoatrial beating rates and induces ERP prolongation of the atrioventricular node in isolated perfused canine hearts.2 In situ, sematilide (1 mg/kg) increases ERP, prolonging cardiac refractoriness, in open-chest dog hearts. Sematilide (0.3-6 mg/kg) inhibits arrhythmias induced by programmed electrical stimulation (PES), but not coronary ligation and reperfusion, two-stage coronary ligation, adrenaline, or digitalis, in dogs.3 Formulations containing sematilide have been used in the treatment of arrhythmias.

References
1. Ishii, Y., Muraki, K., Kurihara, A., et al. Effects of sematilide, a novel class III antiarrhythmic agent, on action potential in guinea pig atrium. Jpn. J. Pharmacol. 68(2), 175-182 (1995).
2. Yamada, A., Motomura, S., and Hashimoto, K. Comparison of direct negative chronotropic and positive inotropic effects of sematilide to those of E-4031 and MS-551 and the reverse frequency-dependent prolongation of cardiac refractoriness of sematilide. J. Cardiovasc. Pharmacol. 27(1), 159-166 (1996).
3. Xue, Y.X., Eto, K., Akie, Y., et al. Antiarrhythmic and proarrhythmic effects of sematilide in canine ventricular arrhythmia models. Jpn. J. Pharmacol. 70(2), 129-138 (1996).