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Tiagabine hydrochloride hydrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tiagabine hydrochloride hydrate图片
CAS NO:145821-57-4
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
Tiagabine hydrochloride hydrate 是一种有效、选择性的 GABA uptake 抑制剂,为抗惊厥剂;在突触体、神经元和神经胶质中,能够抑制 [3H]GABA 的摄取,IC50 值分别为 67,446 和 182 nM。
Cas No.145821-57-4
别名噻加宾盐酸水合物; NO050328 hydrochloride hydrate; NO328 hydrochloride hydrate; TGB hydrochloride hydrate
Canonical SMILESO=C([C@H]1CN(CC/C=C(C2=C(C)C=CS2)/C3=C(C)C=CS3)CCC1)O.[H]Cl.O
分子式C20H28ClNO3S2
分子量430.02
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tiagabine hydrochloride hydrate is a potent and selective GABA uptake inhibitor, used as an anticonvulsant agent, with IC50s of 67, 446 and 182 nM for [3H]GABA uptake in Synaptosomes, Neurons and Glia, respectively[1].

[1]. Braestrup C, et al. (R)-N-[4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl]nipecotic acid binds with high affinity to the brain gamma-aminobutyric acid uptake carrier. J Neurochem. 1990 Feb;54(2):639-47.