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Bis-propargyl-peg9
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bis-propargyl-peg9图片
CAS NO:1351373-47-1
包装:1g
市场价:9700元

产品介绍
Bis-propargyl-PEG9 是一种用于合成 PORTAC 的 PROTAC linker,属于 PEG 类。Bis-propargyl-PEG9 可用于合成二价雌激素受体配体。
Cas No.1351373-47-1
分子式C24H42O10
分子量490.58
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Bis-propargyl-PEG9 is aPEG-basedPROTAC linkerused in the synthesis of PROTACs. Bis-propargyl-PEG9 can be used to synthesize the bivalent estrogen receptor ligands[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. Shan M, et al. Conformational analysis of bivalent estrogen receptor ligands: from intramolecular to intermolecular binding. Chembiochem. 2011 Nov 25;12(17):2587-98.