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Alibiflorin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Alibiflorin图片
CAS NO:39011-90-0
包装:20mg
市场价:1922元

产品介绍
芍药苷是牡丹根中的主要成分,是一种具有神经保护作用的单萜糖苷。
Cas No.39011-90-0
别名芍药内酯苷
化学名((1R,3R,4R,6S,9S)-4-hydroxy-6-methyl-8-oxo-1-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-7-oxatricyclo[4.3.0.03,9]nonan-9-yl)methyl benzoate
Canonical SMILESO=C1O[C@](C2([H])[H])(C([H])([H])[H])[C@@]3([C@@]1(C([H])([H])OC(C4=C([H])C([H])=C([H])C([H])=C4[H])=O)[C@@]([C@]2([H])O[H])([H])C3([H])[H])O[C@]([C@]([C@@]5([H])O[H])([H])O[H])([H])O[C@@](C([H])([H])O[H])([H])[C@@]5([H])O[H]
分子式C23H28O11
分子量480.46
溶解度≥ 48mg/mL in DMSO
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Albiflorin is a major constituent contained in peony root; possesses therapeutic potential for neurodegenerative diseases.IC50 value:Target: in vitro: Albiflorin significantly ameliorated Glu-induced reduction of cell viability, nuclear and mitochondrial apoptotic alteration, reactive oxygen species accumulation, and B-cell lymphoma 2 (Bcl-2)/Bax ratio. Albiflorin also enhanced phosphorylation of AKT and its downstream element glycogen synthase kinase-3β, and this effect was abrogated by the AKT inhibitor LY294002 [1]. in vivo: Mice were exposed to X-ray radiation (400 Roentgen), and both mice and rabbits were intraperitoneally injected with cyclophosphamide (100.0 mg/kg) and cytarabine chloride (92.7 mg/kg), respectively, for 3 days to induce myelosuppression. Albiflorin was subsequently administrated intravenously at low (15.0 mg/kg for mice, 6.00 mg/kg for rabbits), intermediate (30.0 mg/kg for mice, 12.0 mg/kg for rabbits) and high (60.0 mg/kg for mice, 24.0 mg/kg for rabbits) doses, as well as orally (60.0 mg/kg for mice, 24.0 mg/kg for rabbits) for 7 days. Shenqi tablets were used as positive controls (oral administration of 936.0 mg/kg for mice, 336.0 mg/kg for rabbits). The administration of Albiflorin significantly ameliorated myelosuppression in all cases [2].

References:
[1]. Wang D, et al. Neuroprotective effects of paeoniflorin, but not the isomer albiflorin, are associated with the suppression of intracellular calcium and calcium/calmodulin protein kinase II in PC12 cells. J Mol Neurosci. 2013 Oct;51(2):581-90.
[2]. Xu W, et al. Therapeutic effects of combination of paeoniflorin and albiflorin from Paeonia radix on radiation and chemotherapy-induced myelosuppression in mice and rabbits. Asian Pac J Cancer Prev. 2011;12(8):2031-7.