CAS NO: | 39011-90-0 |
包装: | 20mg |
市场价: | 1922元 |
Cas No. | 39011-90-0 |
别名 | 芍药内酯苷 |
化学名 | ((1R,3R,4R,6S,9S)-4-hydroxy-6-methyl-8-oxo-1-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-7-oxatricyclo[4.3.0.03,9]nonan-9-yl)methyl benzoate |
Canonical SMILES | O=C1O[C@](C2([H])[H])(C([H])([H])[H])[C@@]3([C@@]1(C([H])([H])OC(C4=C([H])C([H])=C([H])C([H])=C4[H])=O)[C@@]([C@]2([H])O[H])([H])C3([H])[H])O[C@]([C@]([C@@]5([H])O[H])([H])O[H])([H])O[C@@](C([H])([H])O[H])([H])[C@@]5([H])O[H] |
分子式 | C23H28O11 |
分子量 | 480.46 |
溶解度 | ≥ 48mg/mL in DMSO |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Albiflorin is a major constituent contained in peony root; possesses therapeutic potential for neurodegenerative diseases.IC50 value:Target: in vitro: Albiflorin significantly ameliorated Glu-induced reduction of cell viability, nuclear and mitochondrial apoptotic alteration, reactive oxygen species accumulation, and B-cell lymphoma 2 (Bcl-2)/Bax ratio. Albiflorin also enhanced phosphorylation of AKT and its downstream element glycogen synthase kinase-3β, and this effect was abrogated by the AKT inhibitor LY294002 [1]. in vivo: Mice were exposed to X-ray radiation (400 Roentgen), and both mice and rabbits were intraperitoneally injected with cyclophosphamide (100.0 mg/kg) and cytarabine chloride (92.7 mg/kg), respectively, for 3 days to induce myelosuppression. Albiflorin was subsequently administrated intravenously at low (15.0 mg/kg for mice, 6.00 mg/kg for rabbits), intermediate (30.0 mg/kg for mice, 12.0 mg/kg for rabbits) and high (60.0 mg/kg for mice, 24.0 mg/kg for rabbits) doses, as well as orally (60.0 mg/kg for mice, 24.0 mg/kg for rabbits) for 7 days. Shenqi tablets were used as positive controls (oral administration of 936.0 mg/kg for mice, 336.0 mg/kg for rabbits). The administration of Albiflorin significantly ameliorated myelosuppression in all cases [2]. References: |