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Anemarsaponin B
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Anemarsaponin B图片
CAS NO:139051-27-7
包装:20mg
市场价:1554元

产品介绍
Anemarsaponin B 是一种甾体皂苷。
Cas No.139051-27-7
别名知母皂苷 B
化学名(2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-(((6aS,8aS,8bS,11aS)-6a,8a,9-trimethyl-10-(3-methyl-4-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)butyl)-2,2a,3,4,5,6,6a,6b,7,8,8a,8b,11a,12,12a,
Canonical SMILESCC(CO[C@@]1([H])[C@@](O)([H])[C@](O)([H])[C@@](O)([H])[C@@](O1)([H])CO)([H])CCC(O2)=C([C@@]3([H])[C@]2([H])CC4([H])C(C5([H])CC[C@@]43C)([H])CCC6([H])CC(O[C@@]7([H])[C@@](O[C@@]8([H])[C@@](O)([H])[C@](O)([H])[C@@](O)([H])[C@@](O8)([H])CO)([H])[C@](O)([H])[
分子式C45H74O18
分子量903.06
溶解度≥ 8.77mg/mL in EtOH with ultrasonic and warming
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Anemarsaponin B is a steroidal saponin isolated from the rhizomes of A. asphodeloides (Liliaceae). Anemarsaponin B decreases the protein and mRNA levels of iNOS and COX-2. Anemarsaponin B reduces the expressions and productions of pro-inflammatory cytokines, including TNF-a and IL-6. Anemarsaponin B inhibits the nuclear translocation of the p65 subunit of NF-κB by blocking the phosphorylation of IκBα. Anemarsaponin B also inhibits the phosphorylation of MAP kinase kinases 3/6 (MKK3/6) and mixed lineage kinase 3 (MLK3). Anti-inflammatory effect [1].

References:
[1]. Kim JY, et al. Anti-inflammatory effect of anemarsaponin B isolated from the rhizomes of Anemarrhena asphodeloides in LPS-induced RAW 264.7 macrophages is mediated by negative regulation of the nuclear factor-kappaB and p38 pathways. Food Chem Toxicol. 2009 Jul;47(7):1610-7.