| CAS NO: | 153821-50-2 |
| 包装 | 价格(元) |
| 500µg | 电议 |
| 2.5mg | 电议 |
| Cas No. | 153821-50-2 |
| 别名 | 水生他汀 |
| Canonical SMILES | CC(C=C1OC(C2=C(C=C(C=C2O)O[C@@H]3O[C@@H]([C@@H]([C@@H]([C@H]3O)O)O)CO)CCCCCCCCCCCCCCC)=O)=C(C(O)=C1)C(O)=O |
| 分子式 | C36H52O12 |
| 分子量 | 676.8 |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Aquastatin A is a fungal metabolite originally isolated fromF. aquaeductuumthat has diverse biological activities.1It is active againstS. aureus(MIC = 32 µg/ml) and inhibits enoyl-acyl carrier protein reductase (Fabl; IC50= 3.2 µM) andS. aureusfatty acid synthesis (IC50= 3.5 µM).2Aquastatin A also inhibits the Na+/K+-ATPase and H+/K+-ATPase (IC50s = 7.1 and 6.2 µM, respectively), as well as protein tyrosine phosphatase 1B (PTP1B; IC50= 0.19 µM).1,3 1.Hamano, K., Kinoshita-Okami, M., Minagawa, K., et al.Aquastatin A, an inhibitor of mammalian adenosine triphosphatases from Fusarium aquaeductuum. Taxonomy, fermentation, isolation, structure determination and biological propertiesJ. Antibiot. (Tokyo)46(11)1648-1657(1993) 2.Kwon, Y.-J., Fang, Y., Xu, G.-H., et al.Aquastatin A, a new inhibitor of enoyl-acyl carrier protein reductase from Sporothrix sp. FN611Biol. Pharm. Bull.32(12)2061-2064(2009) 3.Seo, C., Soh, J.H., Oh, H., et al.Isolation of the protein tyrosine phosphatase 1B inhibitory metabolite from the marine-derived fungus Cosmospora sp. SF-5060Bioorg. Med. Chem. Lett.19(21)6095-6097(2009) |
m.cnreagent.com