| CAS NO: | 278605-15-5 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 50mg | 电议 |
| Cas No. | 278605-15-5 |
| 别名 | 4-乙炔基-L-苯丙氨酸HCL,4-Ethynyl-L-phenylalanine |
| Canonical SMILES | N[C@@H](CC1=CC=C(C#C)C=C1)C(O)=O |
| 分子式 | C11H11NO2 |
| 分子量 | 189.21 |
| 溶解度 | DMSO: 2.22 mg/mL (11.73 mM) |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a Ki of 32.6 μM[1]. p-Ethynylphenylalanine selectively and reversibly inhibits the biosynthesis of serotonin[1].p-Ethynylphenylalanine has a low affinity for various recombinant 5-HT receptors (5-HT1, 5-HT2, 5-HT4, 5-HT5, 5-HT6, and 5-HT7)[1]. p-Ethynylphenylalanine (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue[1].p-Ethynylphenylalanine does not inhibit the aromatic amino acid decarboxylase[1]. Animal Model: Male Sprague-Dawley rats (200 g)[1] [1]. Stokes AH, et al. p-ethynylphenylalanine: a potent inhibitor of tryptophan hydroxylase. J Neurochem. 2000 May;74(5):2067-73. |
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