CAS NO: | 67953-08-6 |
包装 | 价格(元) |
10mM (in 1mL DMSO) | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
Cas No. | 67953-08-6 |
别名 | Γ-(P-硝基苯胺)-L-谷氨酸盐酸盐 |
Canonical SMILES | OC([C@@H](N)CCC(NC1=CC=C([N+]([O-])=O)C=C1)=O)=O.[H]Cl |
分子式 | C11H14ClN3O5 |
分子量 | 303.7 |
溶解度 | DMSO: 125 mg/mL (411.59 mM) |
储存条件 | Store at 2-8°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | GPNA hydrochloride is a well known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride is a specific glutamine (Gln) transporter ASCT2 inhibitor. GPNA hydrochloride also inhibit Na+-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na+-independent leucine transporters LAT1/2. GPNA reversibly induces apoptosis in A549 cells[1]. [1]. Corti A, et al. γ-Glutamyltransferase enzyme activity of cancer cells modulates L-γ-glutamyl-p-nitroanilide (GPNA) cytotoxicity. Sci Rep. 2019 Jan 29;9(1):891. |