您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > NCL 00017509
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
NCL 00017509
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NCL 00017509图片
CAS NO:1507367-00-1
包装:1mg
市场价:3425元

产品介绍
NCL 00017509 (compound 6) 是一种有效且不可逆的 Nek2 ((Never in mitosis gene a) 相关激酶 2) 抑制剂。
Cas No.1507367-00-1
Canonical SMILESC#CC1=C2C(NC=N2)=NC(NC3=CC=CC(CC(N)=O)=C3)=N1
分子式C15H12N6O
分子量292.3
溶解度DMSO: 25 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Potent and reversible NIMA related kinase 2 (Nek2) inhibitor (IC50 = 56 nM). Induces increased mitotic abnormalities and mitotic delay. Cell permeable and active in vivo.

Lebraud et al (2014) Model system for irreversible inhibition of Nek2: thiol addition to ethynylpurines and related substituted heterocycles. Org.Biomol.Chem. 12 141 PMID:24213855