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DJ001
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DJ001图片
CAS NO:2161305-12-8
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品介绍
DJ001 是一种高度特异性,选择性和非竞争性的蛋白酪氨酸磷酸酶-σ (PTPσ) 抑制剂,IC50 为 1.43 μM。DJ001 对其他磷酸酶无抑制活性,对蛋白质磷酸酶 5 仅有中等抑制活性。DJ001 促进造血干细胞再生。
Cas No.2161305-12-8
Canonical SMILESO=C(C1=CC=CC=C1)/C=C\NC2=CC=CC([N+]([O-])=O)=C2
分子式C15H12N2O3
分子量268.27
溶解度DMSO: 250 mg/mL (931.90 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

DJ001 is a highly specific, selective and non-competitive protein tyrosine phosphatase-σ (PTPσ) inhibitor with an IC50 of 1.43 μM. DJ001 displays no inhibitory activity against other phosphatases, with only modest inhibitory activity against Protein Phosphatase 5. DJ001 promotes promote hematopoietic stem cell regeneration[1].

[1]. Zhang Y, et al. PTPσ inhibitors promote hematopoietic stem cell regeneration. Nat Commun. 2019 Aug 14;10(1):3667.