| CAS NO: | 40456-50-6 |
| 包装 | 价格(元) |
| 500μg | 电议 |
| 1mg | 电议 |
| Cas No. | 40456-50-6 |
| 别名 | 亚太因 |
| Canonical SMILES | O=C(OC1)[C@H](CC2=CC(OC)=C(OC)C(OC)=C2)[C@H]1CC3=CC=C4C(OCO4)=C3 |
| 分子式 | C22H24O7 |
| 分子量 | 400.4 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Yatein is a lignan that has been found in C. formosana and has diverse biological activities.1,2,3,4 It inhibits the cytochrome P450 (CYP) isoform CYP3A4 (IC50 = 1 μM).1 Yatein inhibits herpes simplex virus 1 (HSV-1) replication in a plaque reduction assay (IC50 = 30.6 μM).2 It induces apoptosis and production of reactive oxygen species (ROS) in, and is cytotoxic to, A549 and CL1-5 non-small cell lung cancer (NSCLC) cells (IC50s = 3.5 and 1.9 μM, respectively).3 Yatein inhibits aggregation of rabbit platelets induced by platelet-activating factor (PAF), collagen, or arachidonic acid in a concentration-dependent manner.4 |1. Usia, T., Watabe, T., Kadota, S., et al. Potent CYP3A4 inhibitory constituents of Piper cubeba. J. Nat. Prod. 68(1), 64-68 (2005).|2. Kuo, Y.-C., Kuo, Y.-H., Lin, Y.-L., et al. Yatein from Chamaecyparis obtusa suppresses herpes simplex virus type 1 replication in HeLa cells by interruption the immediate-early gene expression. Antiviral Res. 70(3), 112-120 (2006).|3. Ho, S.-T., Lin, C.-C., Wu, T.-L., et al. Antitumor agent yatein from Calocedrus formosana Florin leaf induces apoptosis in non-small-cell lung cancer cells. J. Wood Sci. 65:59 , (2019).|4. Chen, J.-J., Chang, Y.-L., Teng, C.-M., et al. Anti-platelet aggregation alkaloids and lignans from Hernandia nymphaeifolia. Planta Med. 66(3), 251-256 (1999). |
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