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LY3295668(AK-01)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
LY3295668(AK-01)图片
CAS NO:1919888-06-4
包装与价格：
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
LY3295668 (AK-01) (AK-01) 是一种有效的、具有口服活性和高度特异性的 Aurora-A 激酶抑制剂，对 AurA 和 AurB 的 Ki 值分别为 0.8 nM 和 1038 nM。
Cas No.1919888-06-4
别名AK-01
Canonical SMILESO=C([C@@]1(CC2=NC(NC3=NNC(C)=C3)=CC=C2F)C[C@@H](C)N(CC4=CC=CC(Cl)=C4F)CC1)O
分子式C24H26ClF2N5O2
分子量489.95
溶解度DMSO : 150 mg/mL (306.15 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

LY3295668 is a potent, orally active and highly specific Aurora-A kinase inhibitor, with Ki values of 0.8 nM and 1038 nM for AurA and AurB, respectively.

LY3295668 is a highly specific Aurora-A kinase inhibitor, with Ki values of 0.8 nM and 1038 nM for AurA and AurB, respectively. LY3295668, a highly specific AurA inhibitor, can kill Rb-deficient cancer cells at doses that have minimal effects on normal cells. In a kinome-wide survey, only 5 of 386 kinases are potently inhibited by LY3295668 (<10 nM)[1].

[1]. Gong X, et al. Aurora-A kinase inhibition is synthetic lethal with loss of the RB1 tumor suppressor gene. Cancer Discov. 2018 Oct 29. pii: CD-18-0469.