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SID 3712249(MiR-544 Inhibitor 1)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SID 3712249(MiR-544 Inhibitor 1)图片
CAS NO:522606-67-3
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
SID 3712249 (MiR-544 Inhibitor 1) (MiR-544 Inhibitor 1) 是一种 miR-544 生物发生抑制剂。 SID 3712249(MiR-544 Inhibitor 1)直接与前体 miRNA 结合。 SID 3712249 (MiR-544 Inhibitor 1) 阻断成熟 microRNA 的产生并减少 miR-544、HIF-1⋱ 和 ATM 转录物。 SID 3712249 (MiR-544 Inhibitor 1) 可用于癌症研究,例如乳腺癌。
Cas No.522606-67-3
别名MiR-544 Inhibitor 1
Canonical SMILESNC1=C2C(C=C(N3CCCC3)N=C2N)=C(C#N)C(N4CCCC4)=N1
分子式C17H21N7
分子量323.4
溶解度DMSO : ≥ 30 mg/mL (92.76 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

SID 3712249 (MiR-544 Inhibitor 1) is an inhibitor of the biogenesis of microRNA-544 (miR-544). Target: MiR-544MiR-544 represses expression of mTOR, promoting tumor cell survival in a hypoxic environment. Inhibition of miR-544 processing with MiR-544 Inhibitor 1 caused apoptosis in triple negative breast cancer cells in response to hypoxic stress, sensitized their response to 5-fluorouracil, and blocked their growth after transplantion into immunodeficient mice. SID 3712249 (MiR-544 Inhibitor 1) is believed to bind directly to the precursor miRNA, blocking production of the mature microRNA and resulting in decreased miR-544, HIF-1α, and ATM transcripts. MiR-544 Inhibitor 1 was as selective and 25-fold more potent than a 2′-O-methyl RNA antagomir.

[1]. Zhi Q, et al. Oncogenic miR-544 is an important molecular target in gastric cancer. Anticancer Agents Med Chem. 2013 Feb;13(2):270-5.