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Target Protein-binding moiety 4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Target Protein-binding moiety 4图片
CAS NO:1300019-38-8
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
1mg电议
5mg电议
10mg电议
50mg电议

产品介绍
Target Protein-binding moiety 4 (Molibresib carboxy acid) 是一种基于 I-BET762 的弹头配体,用于 PROTAC 靶向 BET 的共轭反应。 Target Protein-binding moiety 4 (Molibresib carboxy acid) 是一种 BRD4 抑制剂,pIC50 为 5.1。
Cas No.1300019-38-8
别名Molibresib carboxylic acid; GSK525762A carboxylic acid; PROTAC BRD4-binding moiety 2
Canonical SMILESCC1=NN=C2[C@H](CC(O)=O)N=C(C3=CC=C(Cl)C=C3)C4=C(C=CC(OC)=C4)N21
分子式C20H17ClN4O3
分子量396.83
溶解度DMSO : 7.14 mg/mL (17.99 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Target Protein-binding moiety 4 is a BRD4(1) inhibitor with an IC50 of 7.9 μM.

Target Protein-binding moiety 4 (compound 32) is a BRD4 (1) inhibitor with an IC50 of 7.9 μM[1].

[1]. Yifei Yang, et al. Combined pharmacophore models as virtual screening protocol against BRD4(1) inhibitor. Medicinal Chemistry Research (2016), 25(4), 585-595.