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ASB 14780
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ASB 14780图片
CAS NO:1069046-00-9
包装:5mg
市场价:1838元

产品介绍
ASB 14780 是一种 4-苯氧基衍生物,是胞质磷脂酶 A2α (cPLA2α) 抑制剂,IC50 值为 20 nM。
Cas No.1069046-00-9
Canonical SMILESNC(CO)(CO)CO.OC(CCC1=CC=C2N(C3=CC=C(C=C3)OC4=CC=CC=C4)C=C(C2=C1)CCC5=CC=CC=C5)=O
分子式C31H27NO3.C4H11NO3
分子量582.7
溶解度DMSO|58.27|100|
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Potent and selective cytosolic phospholipase A2 alpha (cPLA2α) inhibitor (IC50 = 20 nM). Selective for cPLA2α over secreted PLA2α (sPLA2α; exhibits no inhibition at 10 μM). Inhibits cPLA2α-dependent inflammatory responses in vitro in guinea pig and human whole-blood assays. Improves diet-induced liver injury and CCl4-induced hepatic fibrosis in vivo. Orally bioavailable.